Wall Street rebounds on Bernanke comments, data

NEW YORK (Reuters) - U.S. stocks rebounded from their worst decline since November on Tuesday after Federal Reserve Chairman Ben Bernanke defended the Fed's bond-buying stimulus and sales of new homes hit a 4 1/2-year high.


The S&P 500 had climbed 6 percent for the year and came within reach of all-time highs before the minutes from the Fed's January meeting were released last Wednesday. Since then, the benchmark S&P 500 has fallen 1 percent.


Bernanke, in testimony on Tuesday before the Senate Banking Committee, strongly defended the Fed's bond-buying stimulus program and quieted rumblings that the central bank may pull back from its stimulative policy measures, which were sparked by the release of the Fed minutes last week.


Bernanke's comments helped ease investors' concerns about a stalemate in Italy after a general election failed to give any party a parliamentary majority, posing the threat of prolonged instability and financial crisis in Europe, and sending the S&P 500 to its worst decline since November 7 in Monday's session.


Bernanke "certainly said everything the market needed to feel in order to get comfortable again," said Peter Kenny, managing director at Knight Capital in Jersey City, New Jersey.


"The fear is we were going to see a rollover, and the first shot over the bow was what we saw out of Italy yesterday with the elections," Kenny said. "When it came to U.S. markets, we saw some of that bleeding stop because our focus shifted from the Italian political circus to Ben Bernanke."


Gains in homebuilders and other consumer stocks, following strong economic data, lifted the S&P 500, and a 5.7 percent jump in Home Depot to $67.56 boosted the Dow industrials. The PHLX housing sector index <.hgx> rose 3.2 percent.


Economic reports that showed strength in housing and consumer confidence also supported stocks. U.S. home prices rose more than expected in December, according to the S&P/Case-Shiller index. Consumer confidence rebounded in February, jumping more than expected, and new-home sales rose to their highest in 4-1/2 years in January.


However, the central bank chairman also urged lawmakers to avoid sharp spending cuts set to go into effect on Friday, which he warned could combine with earlier tax increases to create a "significant headwind" for the economic recovery.


The Dow Jones industrial average <.dji> gained 115.96 points, or 0.84 percent, to 13,900.13 at the close. The Standard & Poor's 500 Index <.spx> rose 9.09 points, or 0.61 percent, to 1,496.94. The Nasdaq Composite Index <.ixic> advanced 13.40 points, or 0.43 percent, to close at 3,129.65.


Despite the bounce, the S&P 500 was unable to move back above 1,500, a closely watched level that was technical support until recently, but could now serve as a resistance point.


The CBOE Volatility Index <.vix> or the VIX, a barometer of investor anxiety, dropped 11.2 percent, a day after surging 34 percent, its biggest percentage jump since August 18, 2011.


The uncertainty caused by the Italian elections continued to weigh on stocks in Europe. The FTSEurofirst-300 index of top European shares <.fteu3> closed down 1.4 percent. The benchmark Italian index <.ftmib> tumbled 4.9 percent.


Home Depot gave the biggest boost to the Dow and provided one of the biggest lifts to the S&P 500 after the world's largest home improvement chain reported adjusted earnings and sales that beat expectations.


Macy's shares gained 2.8 percent to $39.59 after the department-store chain stated it expects full-year earnings to be above analysts' forecasts because of strong holiday sales.


Volume was active with about 7.08 billion shares traded on the New York Stock Exchange, NYSE MKT and Nasdaq, above the daily average of 6.48 billion.


Advancing stocks outnumbered declining ones on the NYSE by a ratio of about 2 to 1, while on the Nasdaq, three stocks rose for every two that fell.


(Reporting by Chuck Mikolajczak; Editing by Jan Paschal; Editing by Jan Paschal)



Read More..

The Lede: Video of Fatal Balloon Crash in Egypt Captured by Witness

Last Updated, 5:59 p.m. As our colleague David Kirkpatrick reports, at least 18 people were killed and three were injured when a high-altitude balloon carrying tourists burst into flames near the Egyptian monuments at Luxor on Tuesday.

According to Egyptian media accounts, the pilot had been pulling a rope to stabilize the balloon as it landed in a field of sugar cane near the southern city of Luxor. A gas hose ripped, the fire began and the pilot and some passengers jumped from the burning balloon before it soared back up into the air and burst into flames.

The Guardian obtained distressing video of the disaster recorded by a passenger in another balloon nearby.

Mohamed Youssef, the pilot of the balloon from which the video of was shot, told the British newspaper that after the fire started when the balloon was close to the ground, “the pilot jumped because the fire was on his body. Another customer near the edge of the balloon jumped.” After those two people jumped from the basket beneath the balloon, Mr. Youssef said, the balloon rose as a result of the loss of weight and the heat. “At 10 to 15 meters, another customer jumped,” he added. “Then it reached 300 feet. Four people jumped. Then the basket separated from the envelope because of the heat. Then it falls to earth.” Mr. Youssef also described the disaster in an interview with the BBC.

The Egyptian television channel Youm 7 broadcast video of the wreckage, which was also shown in images posted online by witnesses.

Video Youm 7 footage of the crash scene.

An Egyptian witness, Mahmoud Mohamed Salem, took photographs of the crash scene, showing remnants of the balloon and the covered remains of victims, and posted them on his Twitter account, while his Facebook photographs showed the recovery efforts.

Several other witnesses described the aftermath of the disaster to news organizations, including France 24 and The Telegraph.

An American photographer, Christopher Michel, was on a balloon trip nearby and posted a series of serene shots of the balloons above Luxor before the accident on his Web site and Twitter feed.

“I heard the explosion just prior to our landing,” Mr. Michel explained in a telephone interview with The Telegraph. He added that over the subsequent hour he and others near the scene started to realize there had been fatalities.

In responses to other photographers who disagreed with his decision to make his photographs on the balloon trip available to news organizations without charge, Mr. Michel wrote that he did not want to profit from the tragedy.

Hot air balloon accidents in Egypt have been documented before in videos and in this report in the Daily Telegraph in 2009.


Read More..

gN2WZW ߣ鐨qʭl q$ :}X,MjVư&0ryUŤޏh, %Et]Aխk#8>4b;KuF1dV@BgyWpZ֬>+ ̲כ#Jv@X8Gň(/EwȉPɕ]Uڌ+mkf˲-+oɫة7>v6ume\Uaʹё(NϢ؈co#е/]5eA{zG1�-/F% 2ɮ6,dיcq! F+3jZ|lZ Xo;y-RvOb_?;OTxi-!O2z롸/Mdf’,@@_OoT;o O$Ǩ64`%Y/h93m&(gJc>S:”N5kExD!Kzf1|M+’X{fu6E݌ 3>.`#Ĩ?Sӌ!c8ʴ)|}R8ѥ)Ncݥdx,iA]w0″L)f|. qN{91؜TWiEO:5`c4ȉ21ԵEH”DŽYt; mp=*a܆y’ԙ>AU?a=LypBL,sŖB”C]Ӧj悌fyn0t?)dD,>”䕙s$ s{tir’.L,3Ui՜FeZu 4Mho&1Ja퍾8u>TY%*:dMvm@R/O(xJ竔ךH 37MqXq,yJ2; G6e\p*)w9=3nӗ|d1+i3En?4jfDgh,7 3|!ew_Mv4N4+a8ņlxf{nO[e C Dw9CX&(.KdZtIhn3Ѷz8rC!`\9~EV/ءaIy EI兗ŽA 4Lc_G]-









Title Post: gN2WZW ߣ鐨qʭl q$ :}X,MjVư&0ryUŤޏh, %Et]Aխk#8>4b;KuF1dV@BgyWpZ֬>+ ̲כ#Jv@X8Gň(/EwȉPɕ]Uڌ+mkf˲-+oɫة7>v6ume\Uaʹё(NϢ؈co#е/]5eA{zG1�-/F% 2ɮ6,dיcq! F+3jZ|lZ Xo;y-RvOb_?;OTxi-!O2z롸/Mdf’,@@_OoT;o O$Ǩ64`%Y/h93m&(gJc>S:”N5kExD!Kzf1|M+’X{fu6E݌ 3>.`#Ĩ?Sӌ!c8ʴ)|}R8ѥ)Ncݥdx,iA]w0″L)f|. qN{91؜TWiEO:5`c4ȉ21ԵEH”DŽYt; mp=*a܆y’ԙ>AU?a=LypBL,sŖB”C]Ӧj悌fyn0t?)dD,>”䕙s$ s{tir’.L,3Ui՜FeZu 4Mho&1Ja퍾8u>TY%*:dMvm@R/O(xJ竔ךH 37MqXq,yJ2; G6e\p*)w9=3nӗ|d1+i3En?4jfDgh,7 3|!ew_Mv4N4+a8ņlxf{nO[e C Dw9CX&(.KdZtIhn3Ѷz8rC!`\9~EV/ءaIy EI兗ŽA 4Lc_G]-
Url Post: http://www.news.fluser.com/gn2wzw-%df%a3%e9%90%a8q%ca%adl-q-xmjvu0ryut%de%8fh-eta%d5%adk84bkuf1dvbgywpz%d6%ac-%cc%b2%d7%9bjvx8gnew%c8%89p%c9%95u%da%8cmkf%cb%b2-o%c9%ab%d8%a97v6umeua%cd%b4/
Link To Post : gN2WZW ߣ鐨qʭl q$ :}X,MjVư&0ryUŤޏh, %Et]Aխk#8>4b;KuF1dV@BgyWpZ֬>+ ̲כ#Jv@X8Gň(/EwȉPɕ]Uڌ+mkf˲-+oɫة7>v6ume\Uaʹё(NϢ؈co#е/]5eA{zG1�-/F% 2ɮ6,dיcq! F+3jZ|lZ Xo;y-RvOb_?;OTxi-!O2z롸/Mdf’,@@_OoT;o O$Ǩ64`%Y/h93m&(gJc>S:”N5kExD!Kzf1|M+’X{fu6E݌ 3>.`#Ĩ?Sӌ!c8ʴ)|}R8ѥ)Ncݥdx,iA]w0″L)f|. qN{91؜TWiEO:5`c4ȉ21ԵEH”DŽYt; mp=*a܆y’ԙ>AU?a=LypBL,sŖB”C]Ӧj悌fyn0t?)dD,>”䕙s$ s{tir’.L,3Ui՜FeZu 4Mho&1Ja퍾8u>TY%*:dMvm@R/O(xJ竔ךH 37MqXq,yJ2; G6e\p*)w9=3nӗ|d1+i3En?4jfDgh,7 3|!ew_Mv4N4+a8ņlxf{nO[e C Dw9CX&(.KdZtIhn3Ѷz8rC!`\9~EV/ءaIy EI兗ŽA 4Lc_G]-
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Kendra Wilkinson Takes Kate Gosselin's Parenting Advice After Celebrity Wife Swap






TV News










02/26/2013 at 05:00 PM EST







Kendra Wilkinson (left) and Kate Gosselin


Giulio Marcocchi/Startraks; Taylor Hill/Getty


When it comes to parenting, Kendra Wilkinson considers Kate Gosselin her mentor.

"If there's any person in this world I'm going to take motherly advice from, it's going to be Kate Gosselin," Wilkinson, 27, told PEOPLE on Friday. "She has eight kids and she knows what she's doing with them. When she told me advice, I listened. With most people, I'm just like, 'Whatever ... whatever, I'm not going to listen to you.' But she's the type I would take advice from."

The two moms connected while filming an episode of Celebrity Wife Swap, which airs Tuesday on ABC (8 p.m. ET). While Wilkinson stayed in Gosselin's Pennsylvania home with her eight kids, Gosselin, 37, ventured to L.A. to live with Wilkinson's hubby Hank Baskett and their 3-year-old son, Hank Baskett IV.

"It was very nerve-racking and I had a lot of anxiety on my end," Wilkinson said of the swap. But, she adds, "Hank's side of things was more the drama. Kate shines the light on things people don't really understand."

Gosselin, it seems, didn't appreciate the couple's more relaxed lifestyle.

"Hank stood up for me and had my back, because I don't think Kate really understands why a man like him is so domestic," the former Girls Next Door star explains. "Hank was like, 'Just chill, relax. These are our rules.' A woman gets to relax and be free. Kate freaked out because she's so used to working and structure and every minute is by the book. But that's not us, though. We're very laid back. We go with the flow."

Still, the reality stars bonded after being out of their respective comfort zones.

"We both got a taste of each other's lives," Wilkinson says of the former Kate Plus 8 star. "We got really close and really in-depth."

She even recommends the Wife Swap experience.

"People should do these swaps more often," she says. "Not just for show, but you really just find this appreciation for your neighbors through this."

Read More..

Wall Street trips and falls on cloudy Italian election

NEW YORK (Reuters) - Stocks on Monday suffered their biggest drop since November after a strong showing in Italian elections by groups opposed to the country's economic reforms triggered worry that Europe's debt problems could once again destabilize the global economy.


The decline marks the biggest percentage drop for the benchmark Standard & Poor's 500 Index since November7, and drove the S&P down to its lowest close since January 18. The CBOE Volatility Index <.vix> or VIX, Wall Street's favorite barometer of fear, surged 34 percent, its biggest jump since August 18, 2011.


Selling accelerated late in the trading session after the S&P 500 fell below the 1,500 level, which has acted as a significant support point. Monday marked the S&P's first close under 1,500 since February 4.


Italy's center-left coalition holds a slim lead over former Prime Minister Silvio Berlusconi's center-right bloc in the election for the lower house of parliament, three TV projections indicated. But any government must also command a majority in the Senate, a race that is decided by region.


The resulting gridlock in parliament could lead to new elections and cast into doubt Italy's ability to pay down its debt.


"Europe hasn't gone away as an issue, it is going to hang around, and it is rearing its ugly head today," said Stephen Massocca, managing director of Wedbush Morgan in San Francisco.


"If someone gets elected who is simply not going to play by the rules, what are they going to do? It puts them in a real quandary here because their financial support, their monetary support is all stipulated by the fact that these austerity programs are going to be in place."


Earlier polls pointing to a center-left victory boosted stocks in Milan and other European markets, and also helped lift the S&P 500 to a session high of 1,525.84 on optimism that Italy would continue down its austerity path.


After a strong start to the year, equities have retreated more recently. The S&P 500's slight fall last week was its first weekly drop after a seven-week string of gains.


In Monday's volatile session, banks and other financial stocks were among the worst performers on worries about the sector's exposure to Italy's massive debt. The KBW Bank Index <.bkx> fell 2.7 percent.


The CBOE Volatility Index <.vix> ended at 18.99, up 34.02 percent.


The Dow Jones industrial average <.dji> dropped 216.40 points, or 1.55 percent, to 13,784.17 at the close. The Standard & Poor's 500 Index <.spx> lost 27.75 points, or 1.83 percent, to 1,487.85. The Nasdaq Composite Index <.ixic> fell 45.57 points, or 1.44 percent, to 3,116.25.


Although the overall market lost ground on Monday, there were a few bright spots.


Barnes & Noble Inc shares shot up 11.5 percent to $15.06 after the bookseller's chairman offered to buy its declining retail business.


Amgen Inc shares climbed 3.1 percent to $89.55, after rival Affymax issued a voluntary recall of its only drug, an anemia treatment that competes with Amgen's top-selling red blood cell booster, Epogen. Affymax shares lost 85.4 percent to $2.42.


The FTSEurofirst-300 index of top European shares <.fteu3> edged up 0.04 percent and Italy's main FTSE MIB <.ftmib> ended up 0.7 percent after earlier gaining nearly 4 percent.


Political uncertainty on the home front, though, is also on Wall Street's mind.


U.S. equities will face a test with the looming debate over so-called sequestration - U.S. government budget cuts that will take effect starting on Friday if lawmakers fail to reach an agreement over spending and taxes. The White House issued warnings about the harm the cuts are likely to inflict on the economy if enacted.


"Sitting out there is the one-thousand-pound gorilla - the sequester issue - and certainly nothing is happening there," said Tim Ghriskey, chief investment officer of Solaris Group in Bedford Hills, New York.


Lowe's Companies Inc lost 4.8 percent to $35.86 after the home improvement retailer posted fourth-quarter earnings.


With 83 percent of the S&P 500 companies having reported results so far, 69 percent beat profit expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data.


Fourth-quarter earnings for S&P 500 companies are estimated to have risen 6 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.


Volume was active with about 7.27 billion shares traded on the New York Stock Exchange, NYSE MKT and Nasdaq, above the daily average of 6.46 billion.


Declining stocks outnumbered advancing ones on both the NYSE and the Nasdaq by a ratio of about 4 to 1.


(Editing by Kenneth Barry, Nick Zieminski and Jan Paschal)



Read More..

Skepticism Surrounds Resumption of Nuclear Talks With Iran





ALMATY, Kazakhstan — Talks between Iran and six world powers over its nuclear program resume here on Tuesday after a break of eight months, but there is a general atmosphere of gloom about their prospects for success, even if narrowly defined.




Since talks in Moscow last June, Iran has continued to increase its stockpile of uranium enriched to 20 percent purity, has begun to install a new generation of centrifuges and has not yet completed an agreement on inspection of suspect military sites with the International Atomic Energy Agency, a deal originally advertised as all but done last May.


With presidential elections in Iran scheduled for June, senior Western diplomats involved with these talks expressed skepticism that Tehran’s chief negotiator, Saeed Jalili, would be willing to make compromises that could be portrayed as weakness at home.


Mr. Jalili is the personal representative of Iran’s supreme leader, Ayatollah Ali Khamenei, considered the dominant voice on the nuclear issue. Ayatollah Khamenei has recently expressed continued mistrust of the United States and its intentions, saying that he would not allow the kind of bilateral talks between Washington and Tehran that most analysts think would be crucial to any resolution.


At the same time, Iran has taken some of its stockpile of 20 percent enriched uranium and converted it into reactor fuel, which cannot easily be turned back. The conversion means that Iran now has less of the uranium needed to make a bomb, reducing the sense of urgency among the six powers, and Israel, that its nuclear program needs to be slowed.


But the total Iranian stockpile of 20 percent enriched uranium has nonetheless grown since November to 167 kilograms from 135 kilograms, according to the most recent I.A.E.A. report — closer to, if still significantly below, the 240 kilograms or 250 kilograms many experts consider necessary, once enriched further, to produce a nuclear weapon.


Iran denies that its nuclear program has any military aim. The six world powers, the so-called P5-plus-1 group, which are the five permanent members of the United Nations Security Council — Britain, China, France, Russia and the United States — and Germany, want Iran to obey Security Council resolutions ordering it to suspend enrichment and open itself up fully to I.A.E.A. inspectors, to ensure that there is no effort to build a nuclear weapon.


To press Iran to comply, the Security Council, the United States and the European Union have created an increasingly painful set of economic sanctions on Iran, as part of a dual-track strategy — negotiations and sanctions. Iran has for its part insisted that as a precondition for serious negotiations, the world should lift all the sanctions and recognize Iran’s “right to enrich,” which Iran asserts it has as a signatory to the Nuclear Nonproliferation Treaty.


The negotiations have been tedious, with Iran appearing to be playing for time, diplomats say. The six powers had asked for a resumption of these talks as early as December, but Iran rejected dates and sites before finally suggesting and agreeing upon Almaty. The choice pleased Western diplomats for its symbolic value, since Kazakhstan, when it became independent of the Soviet Union, freely relinquished the nuclear weapons it had inherited from Moscow. American officials are holding up Kazakhstan, one of the world’s largest producers of uranium and a maker of nuclear fuel, as an example to Iran of the benefits of peaceful nuclear energy and compliance with the I.A.E.A.


President Nursultan Nazarbayev of Kazakhstan appealed to Tehran in a New York Times Op-Ed article in March 2012 to abandon what he suggested was its pursuit of nuclear power status. “Kazakhstan’s experience shows that nations can reap huge benefits from turning their backs on nuclear weapons,” he wrote.


While expectations are low, the six hope to leave here with some momentum and signs of Iranian willingness to engage in what all have agreed should be a reciprocal and step-by-step process of lifting sanctions in return for Iranian actions to comply.


“Iran needs to understand that there is an urgent need to make concrete and tangible progress” in these talks, said Michael Mann, the spokesman for Catherine Ashton, the European Union’s foreign policy chief and chairwoman of the P5-plus-1 group.


Mr. Mann said that the six powers have together “prepared a good and updated offer for the talks which we believe is balanced and a fair basis for constructive talks” and that is “also responsive to Iranian ideas.”


Read More..

Chinese smartphone makers Huawei, ZTE target top tier






BARCELONA (Reuters) – China’s Huawei, little known to consumers just a couple of years ago, is now leading the pack of smartphone makers chasing Apple and Samsung, with ZTE, another Chinese company, snapping at its heels.


Huawei, which sold 32 million smartphones in 2012, up 60 percent on 2011, unveiled its new flagship Ascend P2 smartphone in Barcelona, boasting a connection speed of 150 MB per second, the fastest on the market.






The company was third in smartphone sales in the final quarter of 2012, according to research firm IDC, with ZTE in fifth place and Sony sandwiched in between. Samsung and Apple, however, were far in front with half the market between them.


Wan Biao, chief executive of Huawei Device Co, said the Ascend P2′s faster download speeds would make a difference to customers using 4G networks in countries such as Japan.


The device also includes power-saving technology, developed using expertise from its networks business, which Biao said helped it stand out against other high-end phones running Google’s Android software.


“Our target is for Huawei to provide the best smartphones in the world, better than the iPhone, better than Samsung,” he said in an interview on Monday. “Our target is top three in market share.”


Huawei, which became established by selling unbranded phones to operators, said the Ascend P2 would be available from the second quarter priced at 399 euros, hundred of euros less than flagship devices from its rivals.


Biao said that the company was still establishing itself as a brand in the minds of consumers, so its phones did not attract high subsidies from network operators.


“Operators give a high subsidy to Samsung and Apple,” he said. “We have a very high quality product but the price we set is not as high as these two smartphones; we have to develop differentiated products.”


Analyst Carolina Milanesi at Gartner said the Ascend P2 was a notable step forward for the Chinese company, showing a focus on the most important aspects for consumers, such as speed, an impressive screen and longer battery life.


ZTE, which also developed its technology by making devices for others, is equally ambitious. On Monday, it said it expected to increase smartphone revenue by 30 percent this year.


“We at ZTE consider ourselves as not tier one yet, we see ourselves as tier two, comparable to HTC, Sony and Motorola,” He Shiyou, head of mobile services division, said in an interviewer via a translator. “We have to be as aggressive as possible.”


He said ZTE would reduce its product range to achieve larger sales of fewer models, and focus on the strongest markets for smartphones – the United States, China, Europe and Australia.


It previously took ZTE six months to catch up with the Samsung’s software and hardware specifications, he said, but now it only took a quarter. “We need to close that gap,” he said.


“By 2015, we are hoping to achieve the top three by market share, but in terms of branding image and also pricing segmentation, we want to reach the top five,” he said.


ZTE unveiled a 5.7 inch Grand Memo handset in Barcelona, firmly in the “phablet” screen dimensions that Samsung has popularized in its Note range, and the ZTE Open, a smartphone running on Mozilla’s Firefox OS open ecosystem.


(Reporting by Paul Sandle; Editing by Tim Dobbyn)


Wireless News Headlines – Yahoo! News





Title Post: Chinese smartphone makers Huawei, ZTE target top tier
Url Post: http://www.news.fluser.com/chinese-smartphone-makers-huawei-zte-target-top-tier/
Link To Post : Chinese smartphone makers Huawei, ZTE target top tier
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Norah Jones Snaps Exclusive Oscar Photos for PEOPLE









02/25/2013 at 05:30 PM EST







Norah Jones and Sarah Oda


Courtesy Norah Jones


Talk about a whirlwind day!

Singer Norah Jones shared her first-ever Oscar experience with PEOPLE, snapping exclusive shots as she prepared to walk the big red carpet.

Jones, 33, decided to make it a Hollywood weekend, staying in the Roosevelt Hotel right across from the Dolby Theatre, getting ready with pal Sarah Oda.

After conquering the carpet, Jones took the stage to perform the nominated Best Original Song "Everybody Needs a Best Friend" from Ted.

But the busy singer couldn't even enjoy the evening's parties, as she jetted off to Singapore for work directly from the ceremony.

For more on Norah's night and all the details on Hollywood's biggest night, pick up the new issue of PEOPLE, on newsstands Friday.

Read More..

FDA approves new targeted breast cancer drug


WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.


The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.


Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.


"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."


Cobleigh helped conduct the key studies of the drug at the Chicago facility.


The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.


The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.


Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.


FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.


Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.


FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer


Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.


Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.


Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.


Read More..

Investors face another Washington deadline

NEW YORK (Reuters) - Investors face another Washington-imposed deadline on government spending cuts next week, but it's not generating the same level of fear as two months ago when the "fiscal cliff" loomed large.


Investors in sectors most likely to be affected by the cuts, like defense, seem untroubled that the budget talks could send stocks tumbling.


Talks on the U.S. budget crisis began again this week leading up to the March 1 deadline for the so-called sequestration when $85 billion in automatic federal spending cuts are scheduled to take effect.


"It's at this point a political hot button in Washington but a very low level investor concern," said Fred Dickson, chief market strategist at D.A. Davidson & Co. in Lake Oswego, Oregon. The fight pits President Barack Obama and fellow Democrats against congressional Republicans.


Stocks rallied in early January after a compromise temporarily avoided the fiscal cliff, and the Standard & Poor's 500 index <.spx> has risen 6.3 percent since the start of the year.


But the benchmark index lost steam this week, posting its first week of losses since the start of the year. Minutes on Wednesday from the last Federal Reserve meeting, which suggested the central bank may slow or stop its stimulus policy sooner than expected, provided the catalyst.


National elections in Italy on Sunday and Monday could also add to investor concern. Most investors expect a government headed by Pier Luigi Bersani to win and continue with reforms to tackle Italy's debt problems. However, a resurgence by former leader Silvio Berlusconi has raised doubts.


"Europe has been in the last six months less of a topic for the stock market, but the problems haven't gone away. This may bring back investor attention to that," said Kim Forrest, senior equity research analyst at Fort Pitt Capital Group in Pittsburgh.


OPTIONS BULLS TARGET GAINS


The spending cuts, if they go ahead, could hit the defense industry particularly hard.


Yet in the options market, bulls were targeting gains in Lockheed Martin Corp , the Pentagon's biggest supplier.


Calls on the stock far outpaced puts, suggesting that many investors anticipate the stock to move higher. Overall options volume on the stock was 2.8 times the daily average with 17,000 calls and 3,360 puts traded, according to options analytics firm Trade Alert.


"The upside call buying in Lockheed solidifies the idea that option investors are not pricing in a lot of downside risk in most defense stocks from the likely impact of sequestration," said Jared Woodard, a founder of research and advisory firm condoroptions.com in Forest, Virginia.


The stock ended up 0.6 percent at $88.12 on Friday.


If lawmakers fail to reach an agreement on reducing the U.S. budget deficit in the next few days, a sequester would include significant cuts in defense spending. Companies such as General Dynamics Corp and Smith & Wesson Holding Corp could be affected.


General Dynamics Corp shares rose 1.2 percent to $67.32 and Smith & Wesson added 4.6 percent to $9.18 on Friday.


EYES ON GDP DATA, APPLE


The latest data on fourth-quarter U.S. gross domestic product is expected on Thursday, and some analysts predict an upward revision following trade data that showed America's deficit shrank in December to its narrowest in nearly three years.


U.S. GDP unexpectedly contracted in the fourth quarter, according to an earlier government estimate, but analysts said there was no reason for panic, given that consumer spending and business investment picked up.


Investors will be looking for any hints of changes in the Fed's policy of monetary easing when Fed Chairman Ben Bernake speaks before congressional committees on Tuesday and Wednesday.


Shares of Apple will be watched closely next week when the company's annual stockholders' meeting is held.


On Friday, a U.S. judge handed outspoken hedge fund manager David Einhorn a victory in his battle with the iPhone maker, blocking the company from moving forward with a shareholder vote on a controversial proposal to limit the company's ability to issue preferred stock.


(Additional reporting by Doris Frankel; Editing by Kenneth Barry)



Read More..